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Tokyo Medical and Dental University (東京医科歯科大学, Tōkyō ika shika daigaku) is a Japanese national university located in Bunkyō, Tokyo, Japan. Established in 1928, it was the first national school of dentistry in Japan. TMDU is one of top 9 Designated National University and selected as a Top Type university of Top Global University Project by the Japanese government, and offers baccalaureate and graduate degrees in medicine, dentistry, and related fields. In 2023, the QS world university rankings ranked TMDU 3rd in the world for dentistry and 136th in the world for medicine.

In October 2024, the university will merge with the Tokyo Institute of Technology to form the Institute of Science Tokyo.