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The University of Illinois Chicago (UIC) is a public research university in Chicago, Illinois, United States. Its campus is in the Near West Side community area, adjacent to the Chicago Loop. The second campus established under the University of Illinois system, UIC is also the largest university in the Chicago metropolitan area, having more than 33,000 students enrolled in 16 colleges. It is classified among Doctoral Universities – Very high research activity.

The University of Illinois Chicago traces its origins to several health colleges founded during the late 19th century, including the Chicago College of Pharmacy, which opened in 1859, the College of Physicians and Surgeons (1882), and the Columbian College of Dentistry (1893).

The University of Illinois was chartered in 1867 in Champaign-Urbana, as the state's land-grant university. In exchange for agreeing to the Champaign-Urbana location, Chicago-area legislators were promised that a "polytechnical" branch would open in Chicago.