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The University of Science and Technology of China (USTC) is a public university in Hefei, China. It is affiliated with the Chinese Academy of Sciences, and co-funded by the Chinese Academy of Sciences, the Ministry of Education of China, and the Anhui Provincial Government.

The university was founded in Beijing by the Chinese Academy of Sciences in September 1958. In the beginning of 1970, the university moved to Hefei during the Cultural Revolution. The university has 13 schools, 11 national research platforms, 8 science-education integration colleges, and 5 joint cooperative institutes with local governments.

The university is a member of the C9 League, known as China's Ivy League, Project 211, Project 985, and the Double First-Class Construction.

The university was founded in Beijing by the Chinese Academy of Sciences (CAS) in September 1958. The Director of CAS, Guo Moruo was appointed the first president of USTC. USTC's founding mission was to develop a high-level science and technology workforce, as deemed critical for development of China's economy, defense, and science and technology education. The establishment was hailed as "A Major Event in the History of Chinese Education and Science." CAS has supported USTC by combining most of its institutes with the departments of the university. In 1959, USTC was listed in the top 16 national key universities, becoming the youngest national key university.

In the beginning of 1970, the university moved to Hefei during the Cultural Revolution.

In 2012, USTC and the National University of Defense Technology signed a strategic agreement to cooperate on quantum computing research at a ceremony attended by Pan Jianwei and Yang Xuejun.